LONDON
\nA new type of cancer therapy that uses a common virus to infect and destroy harmful cells is showing big promise in early human trials, say UK scientists.
\nOne patient\u2019s cancer vanished, while others saw their tumours shrink.
\nThe drug is a weakened form of the cold sore virus – herpes simplex – that has been modified to kill tumours.
\nLarger and longer studies will be needed, but experts say the injection might ultimately offer a lifeline to more people with advanced cancers.
\nKrzysztof Wojkowski, a 39-year-old builder from west London, is one of the patients who took part in the ongoing phase one safety trial, run by the Institute of Cancer Research and the Royal Marsden NHS Foundation Trust.
\nHe was diagnosed in 2017 with cancer of the salivary glands, near the mouth. Despite surgery and other treatments at the time, his cancer continued to grow.
\n\u201cI was told there was no options left for me and I was receiving end-of-life care. It was devastating, so it was incredible to be given the chance to join the trial.\u201d
\nA short course of the virus therapy – which is a specially modified version of the herpes virus which normally causes cold sores – appears to have cleared his cancer.
\n\u201cI had injections every two weeks for five weeks which completely eradicated my cancer. I\u2019ve been cancer-free for two years now.\u201d
\nThe injections, given directly into the tumour, attacks cancer in two ways – by invading the cancerous cells and making them burst, and by activating the immune system.
\nAbout 40 patients have tried the treatment as part of the trial. Some were given the virus injection, called RP2, on its own. Others also received another cancer drug – called nivolumab – as well.
\nThe findings, presented at a medical conference in Paris, France, show:
\n\u2022\tThree out of nine patients given RP2 only, which included Krzysztof, saw their tumours shrink
\n\u2022\tSeven out of 30 who had combined treatment also appeared to benefit
\n\u2022\tSide effects, such as tiredness, were generally mild
\nLead researcher Prof Kevin Harrington told the BBC the treatment responses seen were \u201ctruly impressive\u201d across a range of advanced cancers, including cancer of the gullet (oesophagus) and a rare type of eye cancer.
\n\u201cIt is rare to see such good response rates in early stage clinical trials, as their primary aim is to test treatment safety, and they involve patients with very advanced cancers for whom current treatments have stopped working,\u201d he said.
\n\u201cI am keen to see if we continue to see benefits as we treat increased numbers of patients.\u201d
\nIt is not the first time scientists have used a virus to fight cancer. The NHS approved a cold-virus-based therapy, called T-Vec, for advanced skin cancer a few years ago.
\nProf Harrington calls RP2 a souped-up version of T-Vec.
\n\u201cIt\u2019s had other modifications to the virus so that when it gets into cancer cells it effectively signs their death warrant.\u201d
\nDr Marianne Baker, from Cancer Research UK, said the encouraging findings might change the course of cancer treatment.
\n\u201cScientists discovered that viruses could help to treat cancer 100 years ago, but it\u2019s been challenging to harness them safely and effectively.
\n\u201cThis new viral therapy shows promise in a small-scale early trial – now we need more studies to find out how well it works.
\n\u201cResearch suggests that combining multiple treatments is a powerful strategy, and virus therapies like this one could become a part of our toolkit for beating cancer.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"
LONDON A new type of cancer therapy that uses a common virus to infect and destroy harmful cells is showing big promise in early human trials, say UK scientists. One patient\u2019s cancer vanished, while others saw their tumours shrink. The drug is a weakened form of the cold sore virus – herpes simplex – that […]<\/p>\n","protected":false},"author":2,"featured_media":285310,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":{"0":"post-285287","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-world"},"yoast_head":"\n