Pennsylvania
\nHungarian scientist Katalin Kariko and US colleague Drew Weissman, who met in line for a photocopier before making mRNA molecule discoveries that paved the way for Covid-19 vaccines, won the 2023 Nobel Prize for Medicine on Monday.
\n\u201cThe laureates contributed to the unprecedented rate of vaccine development during one of the greatest threats to human health in modern times,\u201d the Swedish award-giving body said in the latest accolade for the pair.
\nThe prize, among the most prestigious in the scientific world, was selected by the Nobel Assembly of Sweden\u2019s Karolinska Institute medical university and comes with 11 million Swedish crowns (about $1m) to share between them.
\nKariko, a former senior vice president and head of RNA protein replacement at German biotech firm BioNTech, is a professor at the University of Szeged in Hungary and an adjunct professor at the University of Pennsylvania (UPenn).
\n\u201cWe are not working for any kind of reward,\u201d Kariko, who struggled for years to find grants for her research, said in remarks alongside Weissman at UPenn\u2019s Philadelphia campus, a few hours after she was awoken by the call from Stockholm. \u201cThe importance was to have a product which is helpful.\u201d
\nCo-winner Weissman, a professor in vaccine research also at UPenn, said it was a \u201clifetime dream\u201d to win and recalled working intensely with Kariko for more than 20 years, including middle-of-the-night emails as they both suffered disturbed sleep.
\nIn 2005, Kariko and Weissman developed so-called nucleoside base modifications, which stop the immune system from launching an inflammatory attack against lab-made mRNA, previously seen as a major hurdle against any therapeutic use of the technology.
\n\u201cWe couldn\u2019t get people to notice RNA as something interesting,\u201d Weissman said on Monday. \u201cPretty much everybody gave up on it.\u201d
\nMass use
\nBioNTech said in June that about 1.5 billion people across the world had received its mRNA shot, co-developed with Pfizer. It was the most widely used shot in the West.
\nHaving grown up in a village in a house without running water or a refrigerator, Kariko got a biochemistry doctorate in Szeged before she and her husband sold their Soviet-made Lada car, sewed some cash into their daughter\u2019s teddy bear and went to the US on a one-way ticket.
\nThe daughter, Susan Francia, became a US national rower and Olympic gold winner.
\nAt UPenn, Kariko tried to turn mRNA into a treatment tool throughout the 1990s but struggled to win grants because work on DNA and gene therapy captured most of the scientific community\u2019s attention at the time.
\nKariko has said she endured ridicule from university colleagues for her dogged pursuit and her failure to secure research grants led to UPenn demoting her from a full-time professor track in 1995.
\nWeissman received his doctorate from Boston University in 1987 and joined UPenn in 1997.
\nThe two have said they met and began chatting in 1998 while waiting for rationed photocopying machine time.
\n\u201cMaybe you have some more copy machines now,\u201d Kariko said at UPenn on Monday. \u201cI bragged about how I can do RNA, and Drew was interested in vaccines, and that is how our collaboration started.\u201d
\nSir Andrew Pollard, an immunology professor at Oxford University who pursued a different technology when co-developing the lesser-used Covid vaccine by AstraZeneca, said it was \u201cabsolutely right that the ground-breaking work\u201d done by Kariko and Weissman should be recognised by the Nobel committee.
\nThe award comes even as Germany\u2019s CureVac, which failed to bring a Covid shot to market, as well as rival Moderna, are separately suing BioNTech and Pfizer for alleged mRNA patent infringements.
\nBioNTech and Pfizer in turn have launched legal challenges against the validity of the intellectual property rights in question.
\nPandemic breakthrough
\nMessenger or mRNA, discovered in 1961, is a natural molecule that serves as a recipe for the body\u2019s production of proteins. Use of lab-made mRNA to instruct human cells to make therapeutic proteins, long regarded as impossible, was commercially pioneered during the pandemic, also by Moderna.
\nProspective mRNA uses include cancer therapies and vaccines against malaria, influenza and rabies.
\nThe medicine prize kicks off this year\u2019s Nobel awards with the remaining five to be unveiled in the coming days.
\nThe prizes, first handed out in 1901, were created by Swedish dynamite inventor and wealthy businessman Alfred Nobel.
\nLast year\u2019s medicine prize went to Swede Svante Paabo for sequencing the genome of the Neanderthal and other past winners include Alexander Fleming, who shared the 1945 prize for the discovery of penicillin.
\n\u201cIf you don\u2019t enjoy what you are doing then you shouldn\u2019t do it,\u201d Kariko said on Monday. \u201cIf you want to be rich, I don\u2019t know the answer for that. But if you would like to solve problems, then science is for you.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"
Pennsylvania Hungarian scientist Katalin Kariko and US colleague Drew Weissman, who met in line for a photocopier before making mRNA molecule discoveries that paved the way for Covid-19 vaccines, won the 2023 Nobel Prize for Medicine on Monday. \u201cThe laureates contributed to the unprecedented rate of vaccine development during one of the greatest threats to […]<\/p>\n","protected":false},"author":2,"featured_media":359722,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":{"0":"post-359704","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-world"},"yoast_head":"\n